Triglyceride-glucose index is associated with poor sleep quality in apparently healthy subjects: A cross-sectional study

ABSTRACT Objectives: We aimed to evaluate the association between the triglyceride glucose index (TyG index) and sleep quality and to establish a cut-off value for the TyG index based on the prevalence of subjects with insulin resistance (IR). Materials and methods: This cross-sectional study involved Brazilian health professionals (20-59 years). A total of 138 subjects answered the Pittsburgh Sleep Quality questionnaire to evaluate sleep quality. They were categorized into two groups: good sleep quality (global score ≤ 5 points) and poor sleep quality (global score ≥ 6 points). Also, we classified the subjects as having a high (>8.08 or >4.38) or low TyG index (≤8.08 or ≤4.38). Results: The majority of the subjects (70%) with high TyG index values (>8.08 or >4.38) reported poor sleep quality (p ≤ 0.001). Those with poor sleep quality had a 1.44-fold higher prevalence of IR (TyG index >8.08 or >4.38) compared to those with good sleep quality, regardless of sex, total cholesterol, LDL/HDL ratio, insulin, complement C3, CRP, and adiponectin (p ≤ 0.001). Conclusion: Our data showed a positive and significant association between the TyG index and poor sleep quality. Thus, these findings support the association between poor sleep quality and IR.

Triglyceride-glucose index is associated with poor sleep quality in apparently healthy subjects: A cross-sectional study.

Objective: We aimed to evaluate the association between the triglyceride glucose index (TyG index) and sleep quality and to establish a cut-off value for the TyG index based on the prevalence of subjects with insulin resistance (IR). Methods: This cross-sectional study involved Brazilian health professionals (20-59 years). A total of 138 subjects answered the Pittsburgh Sleep Quality questionnaire to evaluate sleep quality. They were categorized into two groups: good sleep quality (global score ≤ 5 points) and poor sleep quality (global score ≥ 6 points). Also, we classified the subjects as having a high (>8.08 or >4.38) or low TyG index (≤ 8.08 or ≤4.38). Results: The majority of the subjects (70%) with high TyG index values (>8.08 or >4.38) reported poor sleep quality (p ≤ 0.001). Those with poor sleep quality had a 1.44-fold higher prevalence of IR (TyG index >8.08 or >4.38) compared to those with good sleep quality, regardless of sex, total cholesterol, LDL/HDL ratio, insulin, complement C3, CRP, and adiponectin (p ≤ 0.001). Conclusion: Our data showed a positive and significant association between the TyG index and poor sleep quality. Thus, these findings support the association between poor sleep quality and IR.

Higher Waist Circumference Is Related to Lower Plasma Polyunsaturated Fatty Acids in Healthy Participants: Metabolic Implications.

OBJECTIVE: We evaluated whether the relationship between waist circumference (WC) and cardiometabolic risk is related to usual diet and plasma fatty acid composition. METHODS: This cross-sectional study included 226 health professionals from 20 to 59 years old. Anthropometric features, oxidative stress, inflammatory markers, and plasma fatty acid profile were assessed. Dietary intake was evaluated with a semi-quantitative food frequency questionnaire, the quality of dietary habits by Healthy Eating Index, and insulin resistance by homeostasis model assessment-insulin resistance and triglyceride-glucose index. RESULTS: Higher WC was associated with lower concentrations of high-density lipoprotein cholesterol (p = 0.000) and adiponectin (p = 0.000) and higher uric acid levels (p = 0.011). Plasma polyunsaturated fatty acid (PUFA) levels were negatively associated with weight (p = 0.046), systolic blood pressure (p = 0.035), fasting glucose (p = 0.000), triglyceride-glucose index (p = 0.023), and IL-1ß (p = 0.037). Individuals with elevated WC consumed more calories (p = 0.002), niacin (p = 0.002), and pyridoxine (p = 0.017), but less calcium (p = 0.001), phosphorus (p = 0.016), and vitamin B2 (p = 0.011). In addition, individuals with higher WC denoted lower PUFA concentrations (p = 0.036). CONCLUSION: The results suggest that participants with higher WC have lower plasma PUFA concentrations and higher levels of saturated fatty acids. This could be related to metabolic and inflammatory changes that could trigger increased risk of metabolic syndrome and cardiovascular disease.

Os benefícios da equoterapia em crianças com Síndrome de Down / The benefi ts of hippotherapy in children with Down Syndrome

No tratamento de uma criança com síndrome de Down é necessária uma equipe multidisciplinar, bem como diferentes abordagens terapêuticas. O presente trabalho enfoca o trabalho desenvolvido pela equoterapia e tem por objetivo analisar os impactos da prática terapêutica da equoterapia em crianças com síndrome de Down. Trata-se de uma revisão integrativa da literatura científi ca com amostra fi nal de 12 artigos nacionais e internacionais levantados junto ao PubMed e a Biblioteca Virtual em Saúde (BVS), utilizando-se as bases de dados SciELO, Medline, Lilacs e o Google Acadêmico. Dos artigos investigados, nove são estudos de casos sem grupo controle e três com desenho transversal. Os artigos mostram que essa prática terapêutica se mostra promissora na reabilitação da criança acometida com síndrome de Down. Apesar de serem poucas as abordagens das pesquisas sobre os impactos psicossociais nas crianças com síndrome de Down, os estudos trazem observações positivas. Conclui-se que a prática da equoterapia pode ser considerada como uma abordagem que colabora para o tratamento das crianças com síndrome de Down. No entanto, o nível de evidência apresentado nos estudos demonstra que ainda não há dados conclusivos na literatura científi ca mundial para se julgar benefícios e riscos da equoterapia....(AU)

In the treatment of a child with Down syndrome, a multidisciplinary team is needed, as well as diff erent therapeutic approaches. This work focuses on the work of the hippotherapy and aims to analyze the impacts of the therapeutic practice of hippotherapy in children with Down syndrome. This is an integrative review of the scientifi c literature with a fi nal sample of 12 national and international articles collected from the PubMed and Virtual Health Library (VHL), using the Scielo databases, Medline, Lilacs and Google Scholar. The investigated articles, nine are case studies without a control group and three with cross-sectional design. The articles show that this therapy seems promising practice in the rehabilitation of children aff ected with Down syndrome. Although they are few approaches to research on the psychosocial impact on children with Down syndrome, studies bring positive remarks. It follows that the practice of hippotherapy can be considered as an approach that works for the treatment of children with Down syndrome. However, the level of evidence presented in the studies show that there is no data in the world scientifi cliterature conclusive to judge benefi ts and risks of the hippotherapy....(AU)

LINE-1 and inflammatory gene methylation levels are early biomarkers of metabolic changes: association with adiposity.

We analyzed whether global and inflammatory genes methylation can be early predictors of metabolic changes and their associations with the diet, in a cross-sectional study (n = 40). Higher global methylation was associated to adiposity, insulin resistance, and lower quality of the diet. Methylation of IL-6, SERPINE1 and CRP genes was related to adiposity traits and macronutrients intake. SERPINE1 hypermethylation was also related to some metabolic alterations. CRP methylation was a better predictor of insulin resistance than CRP plasma concentrations. Global and inflammatory gene promoter hypermethylation can be good early biomarkers of adiposity and metabolic changes and are associated to the quality of the diet.